Incorporating spatial dependence into a multicellular tumor spheroid growth model
نویسندگان
چکیده
منابع مشابه
Incorporating Cellular Metabolism into Growth Models of Multicellular Tumor Spheroids
Many chemotherapeutic strategies have failed due to pronounced diffusion limitations in tumors induced by poor vasculaturization. Diffusion limitations, present in threedimensional tissue, produce nutrient deficient regions that eventually become necrotic in tumors in vivo. Multicellular spheroids are better models of in vivo tumors than monolayer cultures because they mimic the heterogeneous m...
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Diffusion limitations in tumors create regions that are deficient in essential nutrients and contain a large number of quiescent and dying cells. Chemotherapeutic compounds are not effective against quiescent cells and therefore have reduced efficacy against tumors with extensive quiescence. We have formulated a mathematical model that predicts the extent and location of quiescence in multicell...
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Multicellular tumor spheroids (MTS) are an in vitro model system of avascular tumors. They are used to study how local microenvironments affect cellular growth, viability, and therapeutic response. We are developing in silico, agent-based analogues to provide new options for gaining exploitable insight into both the in vitro and in vivo systems. MTS exhibit characteristic phenotypic attributes:...
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Most organisms grow according to simple laws, which in principle can be derived from energy conservation and scaling arguments, critically dependent on the relation between the metabolic rate B of energy flow and the organism mass m. Although this relation is generally recognized to be of the form B(m) = m, the specific value of the exponent p is the object of an ongoing debate, with many mecha...
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Multicellular tumor spheroids (MTS) from seven murine solid tumors have been compared in terms of their growth rate and the fraction of the cells that are in cycle. Growth rates ranged from a low of 19 micron/day through a maximum of 106 micron/day, demonstrating a far wider range of growth rates than is observed when the same tumors are grown as monolayers. Through the use of an [125I]iodourid...
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ژورنال
عنوان ژورنال: Journal of Applied Physics
سال: 2005
ISSN: 0021-8979,1089-7550
DOI: 10.1063/1.2146073